Tuberculosis— an infectious disease caused by bacteria Mycobacterium tuberculosis— undernourished people are at the greater risk of developing the disease.
Weight loss, weakness, and shortness of breath are some of the symptoms of Tuberculosis but consumption of foods can be beneficial for tuberculosis patient. A substance has been discovered by the researchers which can fight with the life-threatening bacterium. Beta lactone EZ120, the substance which interferes with the formation of mycomembrane of the bacterium.
Mycomembrane hampers the effect of many medications and fights with the bacteria which develops resistance to antimicrobial drugs and according to the study, it is effective in low concentrations, when combined with the known antibiotics, the effectiveness gets improved to 100-fold. Lead researcher and professor of Organic Chemistry at the Technical University of Munich in Germany said: “Vancomycin, a common antibiotic, and EZ120 work together very well.”
Stephen said that when they used together, the dose can be reduced to 100-fold. Bacteria Mycobacterium tuberculosis’ mycomembrane consists of a lipid double layer, encapsulating the wall of the cell— forms the exterior barrier. Johannes Lehmann of the Technical University of Munich, using the enzyme assays and mass spectroscopy investigations has demonstrated the new inhibitor blocks the enzymes such as Pks13 and Ag85— plays a vital role in the mycomembrane development.
It has been suspected that the mycomembrane disrupt has enabled the antibiotics to enter the bacteria more easily. Stephen said, “This is a new mode of action and might be a starting point for novel tuberculosis therapies.” It has been found that the structured beta lactones could “mask” themselves as mycolic acid metabolic pathways, blocking the decisive enzymes. This research was funded by the German Research Foundation, the National Institutes of Health and the German National Academic Foundation and was published in the journal “Angewandte Chemie International Edition (ANI)”